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In addition, alkaloids, flavonoids, phenolic compounds, and saponins contribute synergistically to the plants adaptogenic and therapeutic properties (89, 90)
Examples of exogenous pigmentations include amalgam tattoo and pigmented hairy tongue
(This explains why hydroquinone has long been used for melasma removal , where brown or gray-brown patches of skin appear on foreheads, cheeks, chins and bridge of the nose.) In smaller doses (of at most 2%), hydroquinone can be purchased over-the-counter but pigment removal products with at least 4% hydroquinone concentration (considered to be the most effective concentration), require a prescription from a skin care specialist
PMID: 28791854
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