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For example, impairments in insulin receptor signaling within the hippocampus and prefrontal cortex can disrupt synaptic plasticity and neurotransmitter balance, potentially leading to cognitive deficits and mood disturbances associated with depression [95]

Besides, the cost deters it from making its way into low- and middle-income countries, where people are not only most affected by obesity, but are also at risk of cardiovascular death, where it makes up nearly 80% of the global burden, according to the National Institutes of Health

Conclusion: The presence of hepatic steatosis does not alter hepatic glucose metabolism in response to glucagon and insulin in concentrations intended to mimic postprandial conditions

(6) Xu J, Zhou L, Liu Y