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However, the factors responsible for the short shelf life of shiitake include moisture loss, color deterioration/ browning, modifications in flavor/aroma, texture, inherent nutritional and biochemical constituents, physical damage, respiration, and microbial attack (Figure 1)

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doi:10.3390/nu13124562 [14] Picard M, McEwen BS

For that reason, many patients try to avoid Accutane, and many doctors view it as a treatment of last resort