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In fact, a randomized, double-blind, placebo-controlled, crossover study involving 114 premenopausal women using a supplement containing a blend of micronutrients and herbal extracts called EstroSense, found that taking the supplement for three months led to markedly higher levels of the protective estrogen metabolite and lower levels of the more dangerous metabolite compared to the placebo.[5] What You Can Do Working with a qualified health care provider can help determine your estrogen load by looking at different lifestyle parameters