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Bottom left : Elevated cytosolic Ca drives sustained muscle contraction and marked metabolic activation, increasing oxygen consumption, ATP utilization, and carbon dioxide production, thereby producing a hypermetabolic state

Its knockout markedly reduced lipid peroxidation and suppressed ferroptosis (Ryan et al., 2023)

Fenderson, J.L., et al

The Interpretive Limitation Finally, the deepest limitation is interpretive: it is tempting to read the solid reconstitution arithmetic as if it validated the doses it computes