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A pilot trial suggested metformin might reduce cognitive decline in people without diabetes, and a large-scale dementia prevention trial with metformin has been proposed in people without diabetes [49,50,51]

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In the cardiovascular system, incretins have been recently associated to the increase of endogenous antioxidant defenses, inhibition of cardiomyocyte apoptosis, attenuation of endothelial inflammation and dysfunction [55]

By incorporating a C18 fatty acid into its acylated peptide structure, survodutides half-life is extended, enabling weekly administration