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You cant take orforglipron and semaglutide if you: Have a personal or family history of medullary thyroid carcinoma (MTC) or a condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Have had a serious allergic reaction to either medication or its ingredients Are pregnant, planning a pregnancy, or breastfeeding Your doctor will also want to know if any of the following apply to you: Past or current pancreatitis or kidney issues Gallbladder problems or a history of gallstones Gastroparesis Planned surgeries or procedures are worth mentioning too, since both medications affect how quickly your stomach empties, and that can interact with anesthesia