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Real-world data show that the GLP-1 receptor agonists semaglutide and tirzepatide not only manage blood sugar and weight but also mirror their heart-protective effects from clinical trials in everyday patients

Surgical interventions typically produce greater and more durable weight loss than pharmacotherapy alone and may be more appropriate than escalating to combination drug regimens with uncertain safety profiles

However, he points out that in extremely rare cases it could lead to pancreatitis, which can be life-threatening in severe cases

Accuracy and reliability of self-reported weight and height in the sister study