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conducted two retrospective cohort studies (2023, 2024) investigating the effects of semaglutide on perioperative outcomes in patients undergoing total knee arthroplasty (TKA) and total hip arthroplasty (THA)

The medication works synergistically with lifestyle modifications rather than replacing them entirely

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To overcome these limitations, a number of pharmacological approaches have been developed over the past decades, but these drugs are generally of fairly limited efficacy, expensive and can in some cases cause significant side effects