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While generally considered safe, long-term or high-dose DFO administration can still lead to neurotoxicity or organ damage (Zhang et al., 2025), and it requires slow infusion due to the risk of hypotension (Gerhardsson, 2022)
Given the complex interactions between the gut microbiome and systemic physiology, dysbiosis, characterized by altered microbial composition and reduced diversity, plays a significant role in the pathogenesis of HN [151]
Diabetes 63 , 407409
AOD-9604 is the same fragment with an N-terminal tyrosine modification developed by Metabolic Pharmaceuticals to stabilize the molecule for clinical development
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