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Peptide Sciences In preclinical biochemical settings, inhibition of NNMT by compounds like 5-Amino-1MQ leads to alterations in intracellular NAD salvage pathways, shifts in methyl donor balance, and downstream metabolic signaling changes

Translating these in vitro findings to an in vivo model, naturally aged male mice from 20-24 months old were treated with FOXO4-DRI

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Introduction With the change of lifestyle and diet structure, the prevalence of type 2 diabetes (T2DM) is on the rise worldwide, and associated complications pose a threat to the life span and quality of life of patients