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were the first time to describe transgenic rats with low brain angiotensinogen behavioral phenotype as characterized by increased anxiety-related behaviors ( Ang II was previously discovered as a pro-hypertensive factor present in areas of the brain associated with cardiovascular and has recently been found to be associated with motor activity, anxiety, learning, and memory ( A R1 (-aminobutyric acid A receptor) ( 1 R ( Furthermore, hyperactivation of AT 1 a receptors is associated with promoting anxiety-like behaviors in the brain ( 1 a receptors (AT 1 a/) from the paraventricular nucleus (PVN) attenuated anxiety-like behaviors in rodents as manifested by increased time spent in the open arms of the EPM ( 1 a/)mice reduced flight behavior in the elevated T-maze test (a model of anxiety and panic) and diminished fear responses despite threat levels ( Chronically infused intracerebroventricular (i.c.v.) AT 2 receptors agonist evokes anxiolytic-like effects ( 2 receptor antagonist PD123319 decreased the open arms exploration in EPM and changed the pattern of swimming during the FST ( 2 receptor-deficient mice increased anxiety-like behaviors, which can be reversed by captopril, and show no depression-like behaviors compared to wild-type mice, providing a theoretical basis for ACEIs for the treatment of emotional disorders ( 2 receptor in the development of depressive-like behavior ( 2 R antagonist PD123319 into the prefrontal cortex reversed the antidepressant effect of losartan ( 2 R has positive effects on depression and anxiety

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doi: 10.1007/s42000-018-0033-5 105 ChartoumpekisDVZirosPGHabeosIGSykiotisGP