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Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies

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The metabolite profile produces free proline, which through proline oxidase generates superoxide, which can react with NO to form peroxynitrite

These results support our preceding research, which revealed a positive association between the MDA level and the increased serum levels of renal function parameters ( Furthermore, the elevated levels of ROS due to AFT exposure led to the deletion of antioxidant status in the renal tissue, as evidenced by significant reductions in GSH, SOD, and GPx in the current study