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Starting at a lower dose is commonly used to assess individual tolerance, since higher starting amounts may be associated with temporary effects such as insomnia , restlessness/anxiety , or fatigue during the adjustment phase

For instance, a propensity to make an excessively intense innate immune response, or on the contrary the unability to control an infection, the pathogen persistence (potentially due to the previous cause), or a suboptimal functioning of mitochondria, leading to an excess production of reactive oxygen species (ROS), or a suboptimal functioning of the neurovegetative nervous system, facilitating the triggering of dysautonomia, or a propensity do develop autoimmune diseases

GI Symptoms Beyond Nausea Diarrhea, constipation, and bloating all occur in a subset of users

Imaging: For significant injuries, follow-up imaging can document structural changes