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[21] Complementary and alternative or integrative medical treatments have been proposed as monotherapies or as add-on adjuncts to other treatment approaches in patients with mild-to-moderate MDD, and the literature review demonstrates a wide list of these complementary treatments

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It works by binding directly to the IGF-1 receptor (IGF-1R) on muscle and other tissue, activating the PI3K/Akt and MAPK signaling cascades that drive cell growth and proliferation

So, its important to talk to your healthcare provider before trying to treat your high cholesterol with over-the-counter niacin supplements