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Basic residues (such as arginine) are paired with nonpolar amino acids (such as proline, alanine, valine and leucine), which have a strong inhibitory effect on tyrosinase (Zu et al., 2023)

For example, glomerular endothelial cells, podocytes, or tubular epithelial cellsall involved in IgA nephropathy pathogenesismay also undergo ferroptosis or modulate mesangial cell ferroptosis via paracrine signaling, yet their roles in amplifying renal injury remain unaddressed

The journey began in the 1980s with research on Gila monster venom, culminating in the discovery of exendin-4, a stable, effective peptide for treating diabetes, demonstrating the progression from initial discovery to blockbuster diabetes medications

Potier, Pierre [Bioorganic and Medicinal Chemistry Letters, 2000, vol