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It is a dual agonist, activating both the GIP (glucose-dependent insulinotropic polypeptide) receptor and the GLP-1 (glucagon-like peptide-1) receptor simultaneously

While weight loss with GLP-1 receptor agonists prior to IVF remains a controversial topic, as a weight loss specialist, I continue to work with patients and my reproductive medicine colleagues to meet patients goals as they relate to weight and fertility. Despite the possible benefits these medications may have on fertility, more research is needed because the medications are still new

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Dans l'essai d'obsit de phase 2 publi dans New England Journal of Medicine , les participants ont t assigns plusieurs groupes de doses : 1 mg, 4 mg, 8 mg et 12 mg , avec des groupes dose plus leve commenant par une dose d'introduction plus faible avant la monte en puissance