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This redox cycle is controlled by glutathione reductase, which catalyzes the conversion of GSSG to active GSH

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Although we were unable to confirm the regression of TLS due to the lack of rebiopsy, together with the previous reports indicating that steroid treatment reduces the size of TLS and that the presence of TLS is correlated with increased proteinuria in IgA nephropathy patients, these findings possibly suggest that urinary GSH levels may reflect the resolution of TLS in certain subpopulations of IgA nephropathy patients

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