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A high biosynthetic and energetic demand of cancer cells drives the broad disregulation of the metabolic pathways that enable tumor cells to survive and grow in the harsh microenvironmetal conditions

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Thomson RL, Buckley JD, Noakes M, Clifton PM, Norman RJ, Brinkworth GD (2008) The effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome