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NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

They exert these protective effects partly by activating the cAMP-CREB signaling pathway and regulating downstream gene transcription

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However, major translational barriers remain, including genotype-specific responses, limited integration of plantsoilmicrobiome dynamics, and the persistent gap between molecular insight and field performance