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Ask: Have you experienced any nausea, constipation, or other side effects? How are you managing your meals and hydration? Reinforce: Side effects are common and often temporary There are ways to manage symptoms effectively Patients should reach out before stopping their medication Text follow-ups Text messaging is an effective tool for ongoing patient engagement

Studies show that these medications can reliably help people lose about 15% of their body weight in six to 12 months

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432 These findings highlight the necessity for advanced imaging studies to further clarify the relationship between CNS alterations and individualized pain phenotypes in PDPN (Fig