NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells
[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Kam T.I., Mao X., Park H., Chou S.C., Karuppagounder S.S., Umanah G.E., Yun S.P., Brahmachari S., Panicker N., Chen R., Andrabi S.A., Qi C., Poirier G.G., Pletnikova O., Troncoso J.C., Bekris L.M., Leverenz J.B., Pantelyat A., Ko H.S., Rosenthal L.S., Dawson T.M., Dawson V.L
The STEP 3 trial added intensive behavioral therapy to both treatment groups and showed even greater results, with semaglutide patients losing an average of 16% of body weight (5)
95%CI 0.57-1.01 vs 0.78, 0.74-0.82