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The extent to which that is actually the case is up for debate

Endothelial dysfunction is a major driver of symptoms in Long COVID, contributing to poor circulation, microclot formation, and impaired oxygen delivery to tissues

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To further validate the above discovery, the authors designed two structurally similar fentanyl derivatives FBD1 (partial agonist) and FBD3 (full agonist), with the aim to obtain OR agonists with reduced/abolished -arrestin signaling but relatively intact G protein activity (Figure 6a)