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Regarding the levels of CRP and TNF-, different studies suggest that their decrease is due to the suppression of the NF-B pathway (nuclear factor kappa-light-chain-enhancer of ac-tivated B cells) and the activation of signals through PPAR- (peroxisome proliferator-activated receptor alpha)

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Retatrutide may become the high-efficacy benchmark if Phase 3 and regulatory review support the early signal