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Description

Glucagon-like peptide-1 ( GLP-1 ) receptor agonists, such as semaglutide (Wegovy) or tirzepatide (Zepbound), reduce hunger and cravings, making it easier to maintain a calorie deficit during plateaus

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These stomach problems typically peak during dose increases and improve over time for most patients

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The GLP-1 agonist, exenatide, increased fasting EF via endothelial nitric oxide (NO) synthase (eNOS) activation, nitric oxide (NO) production in endothelial cells, induced dose-dependent vasorelaxation, and reduced high-glucose or lipid-induced endothelial dysfunction in arterioles ex vivo [64]

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