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The integration of AI in R&D, coupled with synthetic biological systems that mimic metabolic processes and the monitoring of digital biomarkers, could also allow weight management to become more effective, accessible and personalised

Promising evidence of the efficacy of pioglitazone among NAFLD diabetic patients has been demonstrated in a RCT of pioglitazone versus placebo involving 55 subjects, which showed a significant histological improvement of steatosis, inflammation and ballooning, and reduction in liver fat content (assessed by magnetic resonance spectroscopy) after treatment [41]