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Participants were assessed at baseline, 3 months, and 12 months for clinical parameters, dietary intake, and eating behaviors using validated tools (Food Frequency Questionnaire and the Japanese version of the Dutch Eating Behavior Questionnaire [DEBQ-J])

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The peptide has demonstrated efficacy in normalizing pathological blood pressure states, reversing hypertension induced by NOS inhibitors and attenuating hypotension induced by excessive NO substrate administration, indicating adaptive vascular regulation

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