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To address this, we used a series of orthogonal approaches to test the role of NAD(P) + homeostasis in chemotherapy induced infertility, including treatment with the NAD + precursor NMN, along with transgenic overexpression of the NAD + biosynthetic enzymes nicotinamide mononucleotide adenyltransferase 1 and 3 (NMNAT1 and NMNAT3)