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Esta sobreexpresin de SLGT2 aumenta el transporte mximo (Tm) para la glucosa a valores 40-60mg/dl ms altos que el umbral fisiolgico de saturacin (glicemia180mg/dl en sujetos sanos a 240mg/dl en DM2) de manera que la glucosuria se inicia a partir de niveles glicmicos ms elevados a los esperados, lo que se traduce en una mayor reabsorcin de glucosa contribuyendo a mantener la hiperglicemia101,102,106

Ubuka, T., Umemura, S., Yuasa, S., Kinuta, M

At the same time, with the in-depth research on microbiome-targeted therapy and nutritional epigenetics, the exploration of beneficial and non-beneficial nutrients will be more comprehensive, and the efficiency of nutritional intervention will significantly increase

These findings suggest that si-PGC-1 LNP leads to mitochondrial biogenesis and functional decline in T24 cell lines by suppressing the expression of PGC-1