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A single intranasal application of Semax at 50 mcg/kg body weight produces a 1.4-fold increase in BDNF protein levels in the rat hippocampus, accompanied by a 1.6-fold increase in TrkB tyrosine phosphorylation and a 3-fold increase in exon III BDNF mRNA levels

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Additionally, while platelet-based carriers show promise for plaque binding, their large size poses a hindrance to penetrating through thick fibrous caps, limiting their efficiency in reaching pathological immune cells

It details how these compounds interact with immune cells to boost defenses, reduce inflammation, and speed up tissue repair