glp-1 non responders non-responder, back to ol' reliable : r/PCOSloseit Understanding GLP-1 Non-Responders: Key Insights

Increased SREBP activity in the liver results in increased glucose oxidation and increased fat synthesis

Oral glutathione undergoes digestion and liver metabolism, reducing its efficacy

Standard semaglutide titration: Weeks 1-4: 0.25 mg weekly Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Week 13+: 1.7 mg or 2.4 mg weekly (target dose) Hashimoto's-adjusted approach: Weeks 1-6: 0.25 mg weekly (extended to allow thyroid monitoring at week 6) Weeks 7-12: 0.5 mg weekly (TSH check before increasing) Weeks 13-16: 1.0 mg weekly Week 17+: Assess whether higher doses are needed The extended timeline allows for thyroid function checks at each step, ensuring levothyroxine doses are adjusted proactively rather than reactively

38 , e101347 (2019)