Heat, light, and even excessive shaking can break down their structure, making your data unreliable and your experiments a waste of time
Studies in genetically engineered animals may thus underestimate the number of GLP-1R populations in the brain involved in feeding, because, for illustration, it is intrinsically difficult to show whether a sub-population of brain GLP-1Rs mediates 10 or 20% of an effect
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Devi L, Raghavendran V, Prabhu BM, Avadhani NG, Anandatheerthavarada HK