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XL184 also induced marked inhibition of Met and VEGFR2 phosphorylation in cytokine-stimulated human umbilical vein endothelial cells [79]

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The solutions applied to reduce aspartimide formation were using microwaves to reduce the reaction time 125 , or using N--alkyl AspGly dipeptide 126 , or adding 1-hydroxybenzotriazole (HOBt) 127 , Oxyma Pure 128 during the deprotection process