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*Correspondence: Yongjie Zhang, [email protected] These authors have contributed equally to this work

It also discloses a fact most competing timelines omit the foundational Dihexa mechanism papers were retracted in 2025 for image manipulation

The DG-related pathways in the PFC, such as LPC-PC-PA-DG-TG, were significantly activated, while DG degradation pathways, like DG-PC-LPC, were suppressed (171)

Tirzepatide produced greater average weight loss in a direct 72-week obesity trial, while semaglutide has a cardiovascular risk-reduction indication for certain adults