In the STEP 1 trial published in The New England Journal of Medicine , people taking semaglutide lost more than 15% of their body weight over about 16 months

Ingredients Aqua, Glycerin, Glycereth-26, Butylene Glycol, Methylpro Panediol, Vinyl Dimethicone, Niacinamide, 1-2-Hexanediol, Betaine, Isononyl Iso Nonanoate, Isohexadecane, Sodium Polyacrylate, Ammonium Acryloyldimethyltaurat/VP Copolymer, Phenyl Trimethicone, Dimethiconol, Perfum, Chondrus Crispus Powder, C18-21 Alkane, Glutathione, Ethylhexylglycerin, Polyglyceryl-10 Laurate, Glyceryl Acrylate/Acrylic Acid Copolymer, Agar, Xanthan Gum, Hydrogenated Lecithin, Polyglyceryl-10 Oleate, Adenosine, Tromethamine, Acrylates/C10-30 Alkyl, Acrylate Crosspolymer, Glucose, Limonene, Gellan Gum, Thioctic Acid, Caprylic/Capric Triglyceride, Citral, Ceramide NP, Sorbitan Laurate, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetylester, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-1, Soluble Collagen The manufacturer is responsible for the products ingredients

This last point is legally significant because it undermines the argument that the vision loss is caused by underlying diabetes rather than the medication itself
Most people may notice improvements in skin brightness and clarity after 48 weeks of consistent use, depending on lifestyle factors, sun exposure, and overall skin health