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Marginal depletion of B12, which is a less severe lack of the vitamin, is found in a much larger percentage of the general population

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As with other neurodegenerative diseases such as Alzheimers disease, Parkinsons disease, and Huntingtons disease, a significant number of fundamental studies have demonstrated that energy metabolism disorders resulting from mitochondrial dysfunction represent the primary pathophysiological phenotypes of amyotrophic lateral sclerosis (Sassani et al., 2020

Curr Opin Mol Ther 12:790797 Onge EL, Miller SA (2010) Albiglutide: a new GLP-1 analog for the treatment of type 2 diabetes