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Despite obesity being recognized as a chronic, complex disease, insurance and federal programs still do not provide broad coverage to people who live with this disease, the company wrote in a statement

Our understanding of the long-term safety of GLP-1 agonists remains limited, a concern that is particularly pertinent for chronic conditions such as pain and headaches

Furthermore, it slightly reduced the increase of glucose transporter types 1 and 4 (GLUT1/4) during adipogenesis and led to a rise of GLP-1 mRNA, though protein levels remained unchanged