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105 Thus it is reasonable to offer cystoscopy to men and women over the age of 50, since the odds of identifying Hunner lesions are higher in this age group, and the potential benefits of identifying Hunner patients and directing them to more effective therapies (see Statement 19) outweigh the potential risks

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Elevated fibrinogen significantly increases blood viscosity in the microcirculation by increasing the stacking of red blood cells or rouleaux formation