Inhibiting GAPDH in highly glycolytic KRAS or BRAF mutant cells ultimately led to an energy crisis and cell death not seen in their KRAS and BRAF wild-type counterparts
Dale Shepard, MD, PhD: So if you think about this whole concept of stemness and triple negative breast and things, do you think there's other complexes within triple negative that might need to be addressed as well
Activated resident alveolar macrophages (AM) and alveolar type II epithelial cells (AEC II) release cytokines and chemokines (120), recruiting immune cells from circulation to the lungs, including a substantial number of neutrophils (121)
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