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That uncertainty is exactly why it should be used under medical supervision

While serotonins exact role in depression is still being debated, low serotonin levels have traditionally been linked to symptoms such as sadness, low energy, and irritability all of which are often seen in people with major depressive disorder

Interestingly, even normal metabolic processes, like making energy (ATP), generate oxidative byproducts that deplete glutathione stores

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