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100% of completing subjects showed improvement at every facial site assessed

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Here, through metabolomics, transcriptomics, a lung epithelial-specific Cpt1a -knockout mouse model, and clinical analysis, we demonstrate that CPT1A, a key rate-limiting enzyme of fatty acid oxidation, acts with L-carnitine, derived from tumor-associated macrophages to drive ferroptosis-resistance and CD8 + T cells inactivation in lung cancer