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Sustained AR-dependence of CaP that recurs under ADT has historically been linked to ARs transcriptional activity that controls expression of a distinct program of target genes that mediate aggressive behavior

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doi: 10.1016/j.athoracsur.2015.02.060 16 ChandranRSPatilAKPrabhakarRBBalachandranK

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A separate 2024 meta-analysis (Alshammari et al.) confirmed the same conclusion, further strengthening the evidence base

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