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Compared with WT littermate F10 f/f mice, male and female F10 f/f Villin Cre mice showed unaltered postprandial GIP and GLP-1 levels (Figure 1, N and O), as well as IEC transcript levels of Gip and Glp1 and the upstream transcription factors Rfx6 and Pdx1 (Supplemental Figure 3G)

T2D and obesity, by inducing peripheral low-grade inflammation and oxidative stress, aggravate the development of central neuroinflammation and oxidative stress