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Additionally, semaglutide influences reward pathways in the brain, reducing cravings for high-calorie foods and making adherence to healthy eating patterns feel less like deprivation

As a GLP-1, semaglutide works by binding to and activating GLP-1 receptors, which are proteins found throughout the body, including in the pancreas, gut, and brain

Other, newer drugs, such as SGLT2 inhibitors and GLP-1 receptor agonists are now also favored as first-line therapies in some cases, particularly for people who have cardiovascular and/or kidney health concerns in addition to diabetes

As the potency of GLP-1s increases, the conversation around lifestyle interventions is fundamentally changing