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(DAT, NET, and SERT) 10) By utilizing these transporters for its own uptake, amphetamine directly competes with endogenous dopamine, norepinephrine, and serotonin, thereby inhibiting their clearance from the synaptic cleft (Martin & Le, 2023)

This pattern holds biological significance in PD in that it suggests that disease- or treatment-related effects may exert selective pressure on the microbial network in the gut without necessarily lowering the overall number of microbial species present, thereby exerting an influence on GBA signaling and L-DOPA metabolism

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