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In summary, GSNO can be regarded as protective against oxidative stress and a stabilizer and carrier of NO in hypertension (30)

Disease states of GH excess (e.g., acromegaly) and GH deficiency (e.g., congenital isolated GH deficiency) are characterized by increased and decreased GH, IGF-I and insulin levels, respectively, where the GH/IGF-I relationship is reflected by a primary association

doi:10.1523/JNEUROSCI.1779-09.2009 Kurz T, Gustafsson B, Brunk UT (2006) Intralysosomal iron chelation protects against oxidative stress-induced cellular damage

These studies contribute to understanding both efficacy-related aspects and potential risks before the first administration in humans