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In contrast, K149C-D 2 R, a mutant of D 2 R that does undergo desensitization, was observed to facilitate the nuclear localization of the two proteins (Additional file 1: Fig

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su respuesta descrita es no lineal (forma de U) respecto a dosis y tiempo (PMID 6145137), un patrn distinto al de agentes con relacin dosis-efecto ms directa