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This pronounced effect can be attributed to their substantially higher baseline CV risk, driven by a confluence of pathophysiological pathways including endothelial dysfunction, oxidative stress, systemic inflammation [51], volume overload, hypertension [52, 53], hyperphosphatemia, and vascular calcification [54, 55]

McGowan took two low-dose injects of tirzepatide - which is known as Mounjaro - in the two weeks leading up to her death on September 4, the BBC reports

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However, its activation of glucagon receptors offers additional benefits by slowing gastric emptying, which further curbs hunger and promotes weight loss