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Based on these findings, we suggest that novel therapeutic interventions should be sought that involve the combination of active agents, preferably agents with discrete modes of action, and which also exhibit activity against developmental stages, and/or which also ameliorate infection-associated pathology

Beutler E, Moroose R, Kramer L, Gelbart T, Forman L

"[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalized anxiety disorders and neurasthenia]"

These findings suggested that the accumulation of superoxide anions induced by uric acid may be associated with the suppression of p53 activation in VSMCs