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Patients on selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants need closer monitoring if phentermine is used, as serotonin syndrome, though rare, is a medical emergency

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Overdoses have been reported in clinical trials and post-marketing use of liraglutide injection

Proteostasis biomarkers, including HSP expression profiles, autophagy flux indicators, ubiquitinated protein accumulation, and p62/SQSTM1 levels, are increasingly informative regarding prognosis and therapeutic responsiveness